Surgical ventricular reconstruction in mice: Elucidating potential targets for combined molecular/surgical intervention

O17: Potential Benefits of Surgical Intervention in Epilepsy

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Surgical ventricular reconstruction for heart failure.

Congestive heart failure is one of the leading causes of death and complications in the developed world, and coronary artery disease is the major cause of heart failure. Efforts to improve ventricular function, symptoms, and clinical outcomes in patients with heart failure have included neurohormonal inhibition with angiotensin-converting–enzyme inhibitors, angiotensin-receptor blockers, beta-b...

HeartWare Left Ventricular Assist Device Implantation Combined with Surgical Ventricular Reconstruction.

Left ventricular assist devices (LVADs) extend survival of patients with end-stage heart failure as a bridge to transplant or for destination therapy. However, implant of these devices may be challenging, especially in cases of a left ventricular aneurysm involving the left ventricular apical wall. In this report, we describe a symptomatic patient with ischemic cardiomyopathy and a large left v...

Combined surgical left ventricular reconstruction and left ventricular assist device implantation for destination therapy in end-stage heart failure.

End-stage heart failure is a growing problem associated with high mortality, using conventional medical care.1 Although heart transplantation remains the gold standard therapy for end-stage heart failure, it is a limited resource that is not applicable to a large portion of heart failure patients, particularly the elderly. An alternative strategy for patients who do not meet standard heart tran...

Surgical Ventricular Reconstruction for Ischemic or Idiopathic Dilated Cardiomyopathy